Divide & Conquer is a biotechnology company based in Cambridge, UK and working in collaboration with the University of Heidelberg and German Cancer Research Center (DKFZ).
The company is focused on developing new therapeutics against glioblastoma (grade IV astrocytoma), a particularly lethal form of brain cancer, and other solid tumours with very poor life expectancy. Divide & Conquer is funded by VC firm Medicxi.
There is increasing evidence that glioblastoma, and also other solid tumours, form malignant cellular networks between cells through structures known as tumour microtubes and tunneling nanotubes.
These structures allow the trafficking of materials and communication between cells, which appears to be essential for tumour growth and survival , and also resistance to chemotherapy and radiotherapy.
We call this intercellular communication and exchange of materials “Cellular Parabiosis”.
Our aim is to disrupt cellular parabosis in tumours by targeting their ability to form these malignant cellular networks. That means developing therapeutics that target tumour microtubes / tunneling nanotubes and also related cell-to-cell communication structures called gap junctions.